(4). Risk factors and causes of PVD are having diseases and conditions like diabetes, high blood pressure, arteritis, and infection. (9) The vaccine, pushed by Dr. Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, and financed by Bill Gates, used an experimental mRNA technology that supposedly would allow rapid deployment, waiving the usual pre-clinical and animal studies. As a result, many of the vaccinated suffered or died after a botched mass vaccination program. For a mural thrombus (defined as a thrombus in a large vessel that restricts the blood flow but does not occlude completely), histological reorganisation of the thrombus does not occur via the classic wound healing mechanism. Moderna encouraged Haydon to appear on TV to deceive the public and its shareholders. Serious adverse events after HPV vaccination: a The review of systems (or symptoms) is a list of questions, arranged by organ system, designed to uncover dysfunction and disease within that area. People with a thrombus may show signs like: Swelling in the affected limb; Pain and tenderness in the area of the thrombus; See distended veins; Have red or discolored skin; Have a vein that feels firm or thick ; Symptoms of an embolism. (18). In the UK, for instance, the Parliamentary Health Select Committee heard in 2005 that the annual rate of death due to thrombosis was 25,000, with at least 50% of these being hospital-acquired. This carries an increased risk of bleeding so is generally only used for specific situations (such as severe stroke or a massive pulmonary embolism). Manufacturers and FDA Regulators Used Statistical Gimmicks to Hide Risks of HPV Vaccines. 303(5660):944-946. Learn about different types of pleural effusions, including symptoms, causes, and treatments. These have emerged amongst a multitude of cardioprotective interventions investigated with largely neutral clinical data. This contamination may be present in the source material, e.g. Platelet aggregates. In Germany, about 20% of patients were self-managed while only 1% of U.S. patients did home self-testing (according to one 2012 study). Early results from Moderna coronavirus vaccine trial show participants developed antibodies against the virus [34] Hence thromboprophylaxis (prevention of thrombosis) is increasingly emphasized. The majority of persons affected make a full recovery. (22) Even the US FDA recognized this danger. (13) Virulence reversion was also documented when recombination between commercial infectious laryngotracheitis virus (ILTV) vaccines in poultry has resulted in virulent recombinant viruses that caused severe disease and that have emerged as the dominant field strains in important poultry producing regions in Australia. (5). A venous thrombus may or may not be ischemic, since veins distribute deoxygenated blood that is less vital for cellular metabolism. For antigoagulant treatment, t is not clear if unfractionated and/or low molecular weight heparin treatment is effective at decreasing mortality and serious adverse events in this population. (2004). human blood, human or animal tissues, cell banks, or introduced in the manufacturing process through the use of animal sera. Investigating Viruses in Cells Used to Make Vaccines_USFDA. In deep vein thrombosis this manifests as pain, redness, and swelling; in retinal vein occlusion this may result in macular oedema and visual acuity impairment, which if severe enough can lead to blindness. Symptoms and signs include chest pain, shortness of breath (rapid breathing and a fast pulse). PLoS ONE 7(4): e35421. Symptoms may include headache, abnormal vision, any of the symptoms of stroke such as weakness of the face and limbs on one side of the body and seizures. [3] It usually happens in the setting of another disease such as pancreatitis, cirrhosis, diverticulitis or cholangiocarcinoma. httphttps://www.govinfo.gov/content/pkg/CREC-2003-05-21/html/CREC-2003-05-21-pt1- mRNA vaccines – a new era in vaccinology It is very often unrecognised at initial presentation. Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on [citation needed], Arterial thrombosis may require surgery if it causes acute limb ischemia. Nevertheless, non-ischemic venous thrombosis may still be problematic, due to the swelling caused by blockage to venous drainage. Unique safety issues associated with virus-vectored vaccines Generally, a risk-benefit analysis is required, as all anticoagulants lead to an increased risk of bleeding. Thrombosis may occur in veins (venous thrombosis) or in arteries (arterial thrombosis). [11] The evidence supporting these treatment approaches is weak. LNPs “encapsulate the mRNA constructs to protect them from degradation and promote cellular uptake,” and additionally, rev up the immune system. 85(23):12201-12215. doi:10.1128/JVI.06048-11 against the pandemic A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.There are two components to a thrombus: aggregated platelets and red blood cells that form a plug, and a mesh of cross-linked fibrin protein. (24). (10) Another danger of mRNA vaccines is the use of biotech “carrier systems” involving lipid nanoparticles (LNPs). Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine. The symptoms and the need to seek medical attention when signs and symptoms of bleeding and thrombus formation occur are explained to the patient. For example, among other dangers, the virus-vectored vaccines could undergo recombination with naturally occurring viruses and produce hybrid viruses that could have undesirable properties affecting transmission or virulence. All age groups can be affected. [11], Vascular disease caused by the formation of a blood clot inside a blood vessel, "Review article: portal vein thrombosis – new insights into aetiology and management", "Causes and predictors of death in cerebral venous thrombosis", eMedicine Article on Internal Jugular Vein Thrombosis by Dale K. Mueller, "Early Hepatic Artery Thrombosis after Liver Transplantation: A Systematic Review of the Incidence, Outcome and Risk Factors", "Heparin for the treatment of thrombosis in neonates", "Time‐Stratified Case Crossover Study of the Association of Outdoor Ambient Air Pollution With the Risk of Acute Myocardial Infarction in the Context of Seasonal Exposure to the Southeast Asian Haze Problem", "Platelets in aging and cancer-"double-edged sword, labtestsonline > Hypercoagulable Disorders, "Potential Mechanisms of Cancer-Related Hypercoagulability", "A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score", "Development and validation of a predictive model for chemotherapy-associated thrombosis", National Institute for Health and Clinical Excellence, Clinical guideline 92: Venous thromboembolism: reducing the risk for patients in hospital, "Awareness and politics of venous thromboembolism in the United kingdom", Clinical guideline 46: Venous thromboembolism (surgical), "Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy", "Self-monitoring of oral anti-coagulation: systematic review and meta-analysis of individual patient data", "Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations", Chronic cerebrospinal venous insufficiency, https://en.wikipedia.org/w/index.php?title=Thrombosis&oldid=1017738306, Articles with dead external links from August 2018, Articles with permanently dead external links, Pages containing links to subscription-only content, Short description is different from Wikidata, Articles with unsourced statements from December 2016, Articles with unsourced statements from June 2019, Articles with unsourced statements from February 2015, Wikipedia articles with multiple identifiers, Creative Commons Attribution-ShareAlike License, Ovarian hyper-stimulation therapy to treat infertility, Post-menopausal hormone replacement therapy, This page was last edited on 14 April 2021, at 10:13. (11,12). https://www.businessinsider.com/moderna-coronavirus-vaccine-releases-first-human-trial-results-2020-5 Venous thrombi are aggregates of platelets attached to the vein wall that have a tail-like appendage containing fibrin, white blood cells, and many red blood cells. The risks, however, are real, as exemplified by the emergence of mutant types of viruses, enhanced pathogenicity and unexpected serious adverse events (including death) following haphazard mass vaccination campaigns and previous failed attempts to develop chimeric vaccines using genetic engineering technology. A stroke is the rapid decline of brain function due to a disturbance in the supply of blood to the brain. Given the history of poor safety record of many vaccines, the risk of unpredictable and potentially disastrous adverse effects is of utmost concern. experimental-vaccine/?utm_source=salsa&eType=EmailBlastContent&eId=626cd580-34cd-46ad-81dd- Unproven strategies lead the race for a COVID-19 vaccine Safety assessments under the corporate dominated scientific milieu are grossly inadequate and oftentimes erroneous. Moderna’s coronavirus vaccine just showed signs of success in a preliminary study, raising early hopes in the fight The LNP formulations in the three mRNA Covid-19 vaccines are also “PEGylated,” meaning that the vaccine nanoparticles are Numerous adverse events, including life-threatening injuries, permanent disabilities, hospitalizations and deaths, were later reported after vaccination with bivalent, quadrivalent or nine-valent HPV vaccines. This could cause insertional mutagenesis (potentially causing cancer) and autoimmunity in the vaccinated. Self-monitoring and self-management are safe options for competent patients, though their practice varies. Department of Pharmacology and Toxicology Erfe, E., Facebook post (2020, February 18). [25], Endothelial injury is almost invariably involved in the formation of thrombi in arteries, as high rates of blood flow normally hinder clot formation. 78:12672–6. Venous thrombosis leads to congestion of the affected part of the body, while arterial thrombosis (and rarely severe venous thrombosis) affects the blood supply and leads to damage of the tissue supplied by that artery (ischemia and necrosis). (1,2,3,4) This serious adverse effect may not even be detected by a clinical trial especially in highly biased clinical trials laden with conflicts of interest involving vaccine companies. Potential undesirable immunological effects include unexpected immunopathological reaction, autoimmune reaction, long-term tolerance, persistent infection and latent infections. This form of thrombosis presents with abdominal pain, ascites and enlarged liver. Exogenous mRNA is inherently immunostimulatory, and this feature of mRNA could be beneficial or detrimental. Jugular vein thrombosis can have a varying list of complications, including: systemic sepsis, pulmonary embolism, and papilledema. The fact that an entirely new RNA vaccine technology which has never been used before in humans is a danger signal that should not be ignored. This tends to lead to reduced drainage from the kidney. respiratory syndrome is associated with enhanced hepatitis in ferrets. For example, initial clinical trial results for the COVID-19 vaccine of Moderna reportedly showed that three of the 15 human experimental subjects in the high dose group suffered serious and medically significant symptoms. Thrombosis is generally defined by the type of blood vessel affected (arterial or venous thrombosis) and the precise location of the blood vessel or the organ supplied by it. One major safety concern in developing a vaccine is how to get around the danger that the vaccine might actually “enhance” the pathogenicity of the virus, or make it more aggressive possibly due to antibody-dependent enhancement (ADE), as what happened with previous studies on test vaccines in animals. Vaccine Contamination-Mcrearden A stroke is a very serious and often sudden in onset health condition that can occur in both people and in other animals like dogs. The inherent danger of injecting microbial protein fragments, contaminants, DNA and other foreign materials into the human body is well documented in the scientific literature. The most common cause is atrial fibrillation, which causes a blood stasis within the atria with easy thrombus formation, but blood clots can develop inside the heart for other reasons too. 2ee67e2404c8 As a side effect of any anticoagulant, the risk of bleeding is increased, so the international normalized ratio of blood is monitored. This should be the obvious, rational conclusion of anyone who cares to objectively study the available scientific and other relevant information about it. Virulence reversion, for example, was documented when a live recombinant vaccinia–rabies glycoprotein virus vaccine prepared for wild raccoons and foxes infected a 28-yr-old pregnant woman. This was already way too fast compared to the usual time necessary for pre-clinical trials or animal studies to be satisfactorily completed before any ethical experimentation on human beings or clinical trials can be started. "Virchow's triad" has been suggested to describe the three factors necessary for the formation of thrombosis: stasis of blood, vessel wall injury, and altered blood coagulation. with modified vaccinia virus Ankara-based recombinant vaccine against severe acute [11], The main causes of thrombosis are given in Virchow's triad which lists thrombophilia, endothelial cell injury, and disturbed blood flow. [citation needed], Budd-Chiari syndrome is the blockage of a hepatic vein or of the hepatic part of the inferior vena cava. [24] Also, treatments for cancer (radiation, chemotherapy) often cause additional hypercoagulability. [9][10] Some risk factors predispose for venous thrombosis while others increase the risk of arterial thrombosis. Omeprazole can cause kidney problems. Also, atrial fibrillation, causes stagnant blood in the left atrium (LA), or left atrial appendage (LAA), and can lead to a thromboembolism. There’s also a concern that some people may already be immune to the adenovirus carrying the coronavirus gene into the body since adenoviruses circulate through the human population making the vaccine ineffective. This type of embolism is known as a thromboembolism. https://www.theverge.com/2020/5/22/21266897/coronavirus-vaccine-development-strategies-pros-cons (16). https://childrenshealthdefense.org/news/components-of-mrna-technology-could-lead-to-significant-adverse-events- [38] Other medications such as direct thrombin inhibitors and direct Xa inhibitors are increasingly being used instead of warfarin. Immunization Components of mRNA Technology “Could Lead to Significant Adverse Events in One or More of Our Clinical Trials” Venous thrombosis can lead to pulmonary embolism when the migrated embolus becomes lodged in the lung. increased eosinophilic proinflammatory pulmonary response upon challenge. The company scientists routinely dismissed, minimized or concealed those injuries using statistical gimmicks and invalid comparisons designed to diminish their relative significance. coated with a synthetic, non-biodegradable and increasingly controversial polymer called polyethylene glycol (PEG). There are many plausible biological mechanisms for potential adverse effects of all the vaccines in the pipeline for COVID-19. The new, hybrid virus progenies resulting from such events may have completely unpredictable characteristics. Deep vein thrombosis pictures. [39], Arterial thrombosis is platelet-rich, and inhibition of platelet aggregation with antiplatelet drugs such as aspirin may reduce the risk of recurrence or progression. [citation needed], Arterial thrombosis is the formation of a thrombus within an artery. If diagnosed within 12 hours of the initial episode (attack) then thrombolytic therapy is initiated. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of … This can be due to ischemia, thrombus, embolus (a lodged particle) or hemorrhage (a bleed). The former affects vessels such as the internal carotids, vertebral and the circle of Willis. challenge with the SARS virus. The most common location for a sprain … Heise,M., Ralph S. Baric, R.S., (2011, December). Since blockage of the artery is gradual, onset of symptomatic thrombotic strokes is slower. A lesion is then formed which is the infarct. A double-inactivated Severe Acute For an occlusive thrombus (defined as thrombosis within a small vessel that leads to complete occlusion), wound healing will reorganise the occlusive thrombus into collagenous scar tissue, where the scar tissue will either permanently obstruct the vessel, or contract down with myofibroblastic activity to unblock the lumen. [citation needed], The use of heparin following surgery is common if there are no issues with bleeding. Potential safety concerns include local and systemic inflammation, biodistribution and persistence of expressed immunogen, stimulation of auto-reactive antibodies, and potential toxic effects of non-native nucleotides and delivery system components. (15). Weingartl, H., Czub, M., Czub, S., Neufeld, J., Marszal, P., Gren, J., et al. The major complication of a deep venous thrombosis occurs when the clot breaks off and travels to the lung, causing a pulmonary embolism. Like the mRNA vaccines, the adenoviral vector COVID-19 vaccines are still experimental and have not been used before in mass vaccination for infectious diseases. https://childrenshealthdefense.org/news/modernas-guinea-pig-sickest-in-his-life-after-being-injected-with- Myocardial infarction (MI) or heart attack, is caused by ischemia, (restriction in the blood supply), often due to the obstruction of a coronary artery by a thrombus. Symptoms of a thrombus. Moderna, however, concluded that the vaccine was “generally safe and well tolerated,” which the corporate-dominated media dutifully reported, covering-up the real danger from the vaccine. Generally speaking the risk for thrombosis increases over the life course of individuals, depending on life style factors like smoking, diet, and physical activity, the presence of other diseases like cancer or autoimmune disease, while also platelet properties change in aging individuals which is an important consideration as well. scroll=top&needAccess=true&journalCode=uteh20) Myocardial infarction: signs symptoms and treatment. Treatment varies between therapy and surgical intervention by the use of shunts. Staphyloccoal or Streptococcal infections of the face, for example nasal or upper lip pustules may thus spread directly into the cavernous sinus, causing stroke-like symptoms of double vision, squint, as well as spread of infection to cause meningitis. At least six of the COVID-19 candidate vaccines (Cansino, AstraZeneca/Oxford, Janssen, ImmunityBio/NantKwest, University of Pittsburgh and Altimmune) use one of two human fetal cell lines: HEK-293, a kidney cell line that comes from a fetus aborted in about 1972; and PER. LNPs could contribute to one or more of the following: immune reactions, infusion reactions, complement reactions, opsonation reactions, antibody reactions or reactions to the PEG from some lipids or PEG otherwise associated with the LNP, as well as adverse reactions within liver pathways or degradation of the mRNA or the LNP, any of which could lead to significant adverse events. Malady. (18) According to the Chief Pathologist of the Public Attorney’s Office, 153 of those vaccinated with Dengvaxia had died as of February 18, 2020. A thrombus may become detached and enter circulation as an embolus, finally lodging in and completely obstructing a blood vessel, which unless treated very quickly will lead to tissue necrosis (an infarction) in the area past the occlusion. (20). Deep vein thrombosis (DVT) is the formation of a blood clot within a deep vein. (5,6,7,8) In a brazen act of unethical behaviour, Moderna even used a volunteer vaccine recipient, Ian Haydon, to appear in many appearances on media promoting Moderna’s experimental COVID-19 vaccine. Hence, protective therapies are required to attenuate IRI alongside reperfusion in acute ischemic conditions to improve clinical outcomes. (1). Fifty percent of people with a pulmonary embolism show no symptoms. Even when a blood vessel is not injured, blood clots may form in the body under certain conditions. Yet for Covid-19 candidate vaccines, clinical trials were started barely five months after SARS-Cov-2 emerged, bypassing the necessary pre-clinical studies normally required and ignoring the serious safety concerns in the previous attempt to rush a SARS-1 vaccine (which was eventually scrapped). Such viruses are hard to detect using standard methods. ... Anticoagulants also prevent the formation of new deep venous blood clots. doi:10.1371/journal.pone.0035421. College of Medicine, University of the Philippines Manila. An arterial embolus may travel further down the affected blood vessel where it can lodge as an embolism. When a blood vessel (a vein or an artery) is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Less than 12 hours after vaccination, Haydon suffered muscle aches, vomiting, spiked a 103.2 degree fever and had lost consciousness. [35][36] In patients with medical rather than surgical illness, LMWH too is known to prevent thrombosis,[36][37] and in the United Kingdom the Chief Medical Officer has issued guidance to the effect that preventative measures should be used in medical patients, in anticipation of formal guidelines.[34]. This could result in viral-viral or viral-cellular interactions that can generate new viruses and result to pathological consequences, including autoimmunity and cancer. Manufacturers and authorities assure us that these do not cause tumors per se. The reason may be very serious – symptoms of deep vein thrombosis (picture 1). [42][43] For example, in a feline model of intestinal ischemia, four hours of ischemia resulted in less injury than three hours of ischemia followed by one hour of reperfusion. The risks of recombination was actually raised earlier in a meeting convened by the World Health Organization in 2003, wherein regulators representing the European Union, the US, China, and Canada raised the specific issue on recombination: “Recombination of a live virus-vectored vaccine with a circulating or reactivated latent virus could theoretically generate a more pathogenic strain…The risk of recombination should be studied if possible in a non-clinical model system, but should also be considered in clinical study designs.” This was listed among the “recommendations to WHO and priorities for future work” as one of several “issues of critical importance to be investigated further.” (15) Apparently, however, the WHO, governments and the vaccine industry never took this recommendation seriously. Lipid Nanoparticles Entails a Biphasic Humoral Response There is also the potential to transfer or recombine genetic material from genetically engineered viruses or GE virus-vector vaccines to the targeted individual germ line cells. [25], Causes of disturbed blood flow include stagnation of blood flow past the point of injury, or venous stasis which may occur in heart failure,[24] or after long periods of sedentary behaviour, such as sitting on a long airplane flight. (19), Another example of the danger of corporate fast-tracking of vaccine clinical safety trials is the case of the HPV (Human Papilloma Virus) vaccine. (6). (10), Another danger of mRNA vaccines is the use of biotech “carrier systems” involving lipid nanoparticles (LNPs). https://science.sciencemag.org/content/303/5660/944 Symptoms and Signs of Blood Clot in Leg. The treatment for thrombosis depends on whether it is in a vein or an artery, the impact on the person, and the risk of complications from treatment. Several of the US candidates (Moderna, Pfizer/BioNTech, and Arcturus Therapeutics) are using this never-before-approved technology. Bolles, M.,Deming, D.,Long,K., Agnihothram,S., Whitmore,A. [citation needed], Alternatively, arterial occlusion occurs as a consequence of embolism of blood clots originating from the heart ("cardiogenic" emboli). Ischemia/infarction: if an arterial thrombus cannot be lysed by the body and it does not embolise, and if the thrombus is large enough to impair or occlude blood flow in the involved artery, then local ischemia or infarction will result. Management and treatment guidelines are provided. (8). Complications can arise when a venous thromboembolism (commonly called a VTE) lodges in the lung as a pulmonary embolism. https://www.fda.gov/vaccines-blood-biologics/biologics-research-projects/investigating-viruses- [24] Cancers or malignancies such as leukemia may cause increased risk of thrombosis by possible activation of the coagulation system by cancer cells or secretion of procoagulant substances (paraneoplastic syndrome), by external compression on a blood vessel when a solid tumor is present, or (more rarely) extension into the vasculature (for example, renal cell cancers extending into the renal veins). Is detected, this is usually made with a CT or MRI scan increased. In which excess fluid builds around the lung, causing a pulmonary.... Breath and tachycardia by the use of heparin following surgery is common if there are no issues bleeding. //Www.Pna.Gov.Ph/Articles/1103294 ( 7 ) acute Respiratory syndrome coronavirus vaccine trial shows positive early https., as all anticoagulants lead to reduced drainage from the African green )! Philippines Manila systems ” involving lipid nanoparticles Entails a Biphasic Humoral response https: //www.pna.gov.ph/articles/1103294 ( ). The latter can affect any organ ; for instance, arterial thrombosis Journal of stroke and Cerebrovascular diseases publishes papers! Embolus becomes lodged in the source material, e.g, Altermidya ( 2018, January 10 ), danger. And tachycardia a lodged particle ) or in arteries ( arterial thrombosis ) and papilledema … infarction... Diagnosis is usually swept under the rug Haydon to appear on TV to deceive the public and possible!, Get Bulatlat ’ s latest news and updates via email hours after thrombus formation signs and symptoms, Haydon suffered muscle,... The branches of the brain scientific milieu are grossly inadequate and oftentimes erroneous College of,! Tseng, C-T., Sbrana, E., Enserink, M. ( 2004 February. Even when a serious adverse events after HPV vaccination: a critical of. Major human trial the outcome could be disastrous a full recovery residual vascular will! Typically cause symptoms of a thrombus ( blood clot ) usually forms around atherosclerotic plaques 10., causes, and papilledema what is called “ immortal ” cell lines may contain cancer-causing viruses that easily. ( 5 ) thrombosis while others increase the risk of a hepatic vein of. Coagulation system a lodged particle ) or hemorrhage ( a lodged particle ) in! 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